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Akkermansia Muciniphila: Bane or Boon for IBD?

Alyssa Luck · Mar 21, 2021 · Leave a Comment

Summary: Akkermansia muciniphila is a commensal bacteria found in healthy human colons that is widely regarded as a promising next-generation probiotic. Researchers have mainly focused on therapeutic potential for obesity and diabetes, but there’s also substantial interest in the field of IBD, particularly for its beneficial effects on gut barrier function. However, a minority of researchers have suggested that Akkermansia muciniphila could worsen colitis. Despite that, most of the evidence thus far suggests that A. muciniphila could potentially be leveraged as a beneficial therapy for IBD and gut health in general once more research has been done.

This post is part of the IBD Index.

Table of Contents
Akkermansia Muciniphila: Fast Facts
Akkermansia Muciniphila Degrades Colonic Mucus – But That’s a Good Thing
Akkermansia Muciniphila Strengthens the Gut Barrier
Akkermansia Muciniphila May Promote Intestinal Wound Healing
Akkermansia Muciniphila May Modulate Immune Response to Commensal Bacteria
From Mechanisms to Colitis Models in Mice
Schrödinger’s Bacteria: Akkermansia Muciniphila Both Promotes and Ameliorates Colitis
So What Does This Mean for Humans with IBD?
Akkermansia Muciniphila and IBD? It’s Complicated.
Should I Take Akkermansia Muciniphila?

Lactobacillus and Bifidobacteria species may still be the darlings of the probiotic world, but there’s a new kid on the block: Akkermansia muciniphila.

This bacteria was isolated for the first time in 2004 (1) so it’s still relatively new to the game, but you can see from this fun trend analysis (2) that research has exploded, especially in the last couple years.

Source: Hojat et al., Global scientific output trend for Akkermansia muciniphila research: a bibliometric and scientometric analysis, 2020

So what is Akkermansia muciniphila, and why the interest all of a sudden?

Akkermansia Muciniphila: Fast Facts

Akkermansia muciniphila is part of a normal, healthy microbiome in humans, typically comprising 3-5% of the total bacteria in the gut (which is one of the largest contributions by a single organism, at least that we know of). (3, 4)

It’s a mucosa-associated bacteria, meaning it lives close to the epithelial cells of the intestine, and its preferred food is intestinal mucus (notice the Latin roots “mucin” and “phil” in its name? It literally means mucin-loving!). (1)

Quite a few observational studies have found an association between reduced levels of Akkermansia muciniphila and several disease states, including: (3, 5, 6)

  • obesity
  • diabetes
  • metabolic syndrome
  • liver disease
  • autism (7)
  • aging (8)
  • asthma (9)
  • appendicitis (10)

and finally, most relevant to our interests,

  • ulcerative colitis (11, 12, 13, 14, 15, 16)
  • Crohn’s disease (17, 18)

Note: As is usually the case, the literature doesn’t reach perfect consensus, and not every analysis has found a negative correlation between A. muciniphila abundance and IBD. For instance, one study found comparable levels of A. muciniphila in patients with IBD vs. healthy controls (with the exception of pediatric Crohn’s disease) (18), and another actually found higher levels of A. muciniphila in pouchitis compared with healthy controls (19). But the vast majority of evidence points to a negative correlation.

There’s also already some fairly promising interventional research investigating A. muciniphila as a therapy for obesity, diabetes, metabolic syndrome, and as a concurrent therapy to increase the efficacy of certain cancer treatments. (3, 5, 20, 21) Of particular note are two pilot trials in humans: one on overweight/obese insulin resistant volunteers and another on patients with type II diabetes. (22, 23) Both of these trials found that supplementation with A. muciniphila was safe and well-tolerated over a 3-month period, and improved glucose control as well as several other markers related to metabolic syndrome.

So that’s a quick and dirty summary of where we’re at with A. muciniphila research in general. With that out of the way, I want to focus on the potential relevance of Akkermansia muciniphila to IBD, beginning with a closer look at its role in the ecosystem of the gut.

Akkermansia Muciniphila Degrades Colonic Mucus – But That’s a Good Thing

As mentioned, the primary metabolic activity of A. muciniphila is mucus degradation. Knowing how important mucus is to the health and protection of our colon, this may initially sound like a bad thing (and as you’ll see, some researchers claim that it is). But in a healthy gut, most agree that Akkermansia muciniphila and its mucus-degrading activities fill a vital ecological niche. (4, 24, 25)

Only a few members of the intestinal microbiota have the ability to metabolize mucin, but these mucin-degraders liberate several by-products that in turn support the growth of other commensal flora, including numerous species of butyrate producers.

As most of you probably know, butyrate is the preferred fuel of colonocytes (the epithelial cells of the colon), so anything that increases butyrate production is extremely beneficial to gut health. And this increased production of butyrate allows colonocytes to produce more mucin, completing the synergistic cycle. Other beneficial products of this cycle include vitamin B12, 1,2-propanediol, and propionate (which is another short-chain fatty acid like butyrate). (26)

In addition to its natural role in this colonic ecosystem, there’s also some evidence that supplementing A. muciniphila can increase mucin production and thickness of the colonic mucus layer, at least in mice. (11, 25) For instance, in a mouse model of accelerated aging, long-term supplementation with A. muciniphila prevented age-related decline in the thickness of the colonic mucus layer, in fact increasing the thickness approximately 3-fold. (27)

Akkermansia Muciniphila Strengthens the Gut Barrier

An oft-repeated claim in the literature on A. muciniphila that is of great relevance to IBD is that it improves gut barrier function – in other words, it helps make sure that the tight junctions between the epithelial cells of the intestine stay tight, so that no bacteria or large food molecules slip into the bloodstream unauthorized. Indeed, one of the review papers I cite below refers to A. muciniphila as “a sentinel for gut permeability,” and another calls it “the gatekeeper of our mucosa.” (28, 4) That’s high praise!

This claim is primarily supported by in vitro data (such as this widely-cited study (29) using human colonic cell lines) and mouse data demonstrating reductions in circulating lipopolysaccharides (LPS) and/or increases in the expression of tight junction proteins in response to supplementation with A. muciniphila (or, in a couple cases, isolated components of the bacteria). (30, 31, 32, 33, 34) These studies often show that A. muciniphila increases mucus production as well, in line with the previous section.

Another experiment didn’t directly test A. muciniphila, but found that the traditional Japanese herbal medicine Bofutsushosan significantly increased A. muciniphila abundance and resulted in improved gut barrier function (by several measures). (35)

But of special note is the first clinical evidence we have in humans, which corroborates these findings. The first human pilot study, which tested A. muciniphila supplementation in overweight and obese volunteers, observed a statistically significant decrease in circulating LPS in the group receiving a pasteurized A. muciniphila supplement for three months, both compared to baseline and compared to the placebo group. (22)

Akkermansia Muciniphila May Promote Intestinal Wound Healing

One additional activity of A. muciniphila that – if confirmed in humans – is highly relevant to IBD is its potential role in intestinal wound healing. It is well established that certain changes occur in the intestinal microenvironment when epithelial tissue is damaged, and one group of researchers identified A. muciniphila as a key player. (36, 37)

Not only did they find that abundance of A. muciniphila drastically increased in the wounded area, they also found that administering A. muciniphila to mice (rectally) enhanced wound healing compared with controls by promoting enterocyte proliferation.

But, of note – although I’ve seen several papers make conclusive-sounding statements that A. muciniphila promotes wound healing, I have yet to see any additional supporting evidence aside from that one mouse study.

There is a fair bit of evidence showing that A. muciniphila abundance increases in mice after administration of DSS (38, 39, 40), which does support a correlation with wound healing (since DSS injures the intestinal mucosa), but it certainly does nothing to prove that it plays an active helpful role in the process. So as far as I can tell, this one study is all we’ve got for this mechanism, and any conclusive claims are probably a tad premature.

(Although weirdly, I came across a study that A. muciniphila improves healing of bone fractures in mice. (41) The mechanism is different, of course, but interesting nonetheless!)

Akkermansia Muciniphila May Modulate Immune Response to Commensal Bacteria

Another point of relevance to IBD is the potential role of A. muciniphila in promoting a balanced and healthy immune response to bacteria in the gut (because as we know, one of the disease mechanisms in IBD is thought to be a dysregulated immune response to commensal bacteria). (42)

One experiment using human cell lines found that the TNF-α/IL-10 cytokine induction ratio, which is often used to measure the inflammatory potential of emerging probiotics, was lower in A. muciniphila in comparison to two other known commensal bacteria, indicating a greater anti-inflammatory capacity. (43) However, they were careful to note that A. muciniphila “cannot be strictly defined as anti- or pro- inflammatory, but may instead have a more complex role in preserving the balance of the gut ecosystem.”

Interestingly, some evidence in mice shows that A. muciniphila is one of only a small number of commensal intestinal species that induces an antigen-specific T-cell mediated immune response during homeostasis. (44) (Until recently it was thought that this type of immune response to commensal bacteria only occurred in the context of a disrupted gut barrier or other state of dysfunction, not in a state of homeostasis).

Another set of experiments found that extracellular vesicles derived from A. muciniphila also had immunomodulatory effects. In vitro pretreatment with these EVs ameliorated the production of IL-6 (an inflammatory cytokine) from colon epithelial cells in response to a component of E. coli. (45) Additionally, they found that oral supplementation with these EVs protected against DSS-induced colitis in mice.

From Mechanisms to Colitis Models in Mice

All four of these mechanisms – promotion of mucus production, strengthening of gut barrier, intestinal wound healing, and immune modulation – would suggest a beneficial role of Akkermansia muciniphila in IBD, and indeed, most researchers writing on the topic so far have come to that conclusion.

But what have we learned from experiments that actually pit Akkermansia muciniphila against animal models of colitis* in the metaphorical fighting ring? The results, as you’ll see, are mixed. And not only that, in many cases, researchers appear to be entirely unaware that other scientists in this same small field are saying the exact opposite of them. Fascinating, right? (Or disheartening?)

*I discuss this in far more detail in this post on animal models of colitis, but note that although animal models are extremely useful in the field of IBD research and are used extensively (and in many cases are the best we’ve got!), it would be incorrect to call them animal models of IBD, because the disease states achieved in these models are still insufficiently similar to human IBD to have direct practical therapeutic relevance.

Schrödinger’s Bacteria: Akkermansia Muciniphila Both Promotes and Ameliorates Colitis

This is where the plot thickens (much like the mucosal layer in response to Akkermansia muciniphila, one could say).

The first experiment I’m aware of that specifically investigated the effect of A. muciniphila in a mouse model of colitis was published in 2013, and is a particularly interesting one because they tested both live A. muciniphila as well as extracellular vesicles (EVs) derived from the bacteria. (45) Unexpectedly, while administration of the EVs significantly ameliorated the effects of DSS-induced colitis, administration of A. muciniphila itself made the colitis worse.

Another experiment, published almost simultaneously, found that administration of A. muciniphila exacerbated pathogen-induced intestinal inflammation in gnotobiotic SIHUMI mice (germ-free mice that were colonized with a “simplified human intestinal microbiota” (aka SIHUMI) of eight strains). (46)

On the other hand, a couple papers published very recently found that, contrary to those results, administration of A. muciniphila actually improved DSS-induced colitis in mice (47, 48) A third study that wasn’t even investigating colitis directly (it’s actually the bone-healing study I mentioned earlier) nonetheless found that A. muciniphila ameliorated the effects of DSS by strengthening the gut barrier. (41)

One group of researchers tested A. muciniphila in a different mouse model of colitis, the IL-10 knockout mouse, and found that colitis was significantly exacerbated both in gnotobiotic mice and germ-free mice monocolonized with A. muciniphila. (49) But a few years later, another group of researchers replicated those experiments using a different strain of A. muciniphila and found no evidence of a pro-inflammatory effect. (50) (This paper is an excellent one to read if you want to better understand the nuances of the existing A. muciniphila research in mouse models of colitis. The authors do a really excellent job summarizing and explaining things.)

Two additional papers suggest a potentially colitogenic effect of A. muciniphila, but by proxy – they did not administer A. muciniphila directly, but the tested interventions that worsened colitis (a low-fiber diet and a high-glucose diet, respectively) were found to markedly increase A. muciniphila abundance, and both papers suggested this increase as a potential mechanism behind the colitis exacerbation. (51, 52)

In contrast, three other papers suggest an anti-inflammatory effect by proxy: “Chlorogenic Acid Ameliorates Experimental Colitis by Promoting Growth of Akkermansia in Mice,” (53) “Caffeic acid ameliorates colitis in association with increased Akkermansia population in the gut microbiota of mice,” (54) and “Lactobacillus pentosus Increases the Abundance of Akkermansia and Affects the Serum Metabolome to Alleviate DSS-Induced Colitis in a Murine Model.” (55) (Gotta love descriptive titles, hey?)

All of the researchers who observed colitogenic effects from A. muciniphila posited the same potential mechanism: that as a mucin-degrader, A. muciniphila may cause thinning of the protective colonic mucus layer in certain contexts, making the epithelial cells more vulnerable and easily accessed by inflammation-inducing pathogens. It would therefore act as a pathobiont, i.e. a commensal species that can become a contributor to disease in certain contexts.

But notably, those writing the most recent of these negative papers (52) appear to be almost completely unaware of the rest of the body of evidence on A. muciniphila and colitis, or – more broadly – A. muciniphila and gut health. It’s a bit hard for me to take their conclusions (that A. muciniphila is colitogenic) seriously when they don’t even acknowledge the widely disparate results from other experiments and the overall tenor of the existing research. (I talked (ranted?) more about this on a YouTube stream with my friend Kyle.)

So What Does This Mean for Humans with IBD?

Clearly, context matters greatly here, which should come as no great surprise. After all, in a healthy colon, A. muciniphila acts in symbiosis with a diverse community of intricately interwoven organisms – a far cry from gnotobiotic mice with a simulated microbiome comprising 8 species.

We’ve seen that while negative effects have been observed in mouse models of intestinal inflammation, including some of those often used to model IBD, this has not been observed across the board, with most studies concluding the opposite. But more importantly, as discussed in a previous article, those models have limited to no translational relevance in the absence of corroborating data in human trials.

So, what data do we have in humans? To my knowledge, the only interventional data we have is the two pilot trials I mentioned earlier on diabetes and metabolic syndrome. If you’ll recall, both found the supplement to be well-tolerated, and one found that a pasteurized A. muciniphila supplement lowered circulating LPS levels in the participants.

Of specific relevance to IBD, we do also have some data from FMT trials for UC patients, where one analysis found that stool from donors with a high relative abundance of Akkermansia muciniphila was more likely to induce remission in patients with refractory UC. (56)

Akkermansia Muciniphila and IBD? It’s Complicated.

There’s more one could dig into here (for instance, what of the observation that A. muciniphila exhibits increased binding to mucin isolated from UC patients vs. healthy controls? (13, 57) Or its affects on serotonin in the gut? (58)) but to avoid getting even further into the weeds, the bottom line is that the effects of Akkermansia muciniphila on gut health appear to be context-dependent, and we don’t yet have enough data to draw conclusions for human IBD.

However, the preponderance of evidence, including the human data we have, points to a beneficial role and therapeutic potential for IBD. Further, the evidence that researchers have invoked to accuse A. muciniphila of being “colitogenic” is extremely limited. Unless I’m missing any (and please tell me if I am!), that evidence comprises three mouse experiments directly testing A. muciniphila, plus two additional experiments making mechanistic inferences based on correlations. Further, the negative results of one of those mouse experiments failed to be replicated by another group of researchers when they tried to repeat the experiment.

Should I Take Akkermansia Muciniphila?

I think the research so far is promising, and given research trends and the growing popularity of probiotics, I expect to see more developments in this area soon.

For now, the probiotic formulation tested in the human diabetes trial is already on the market under the brand Pendulum (marketed for diabetes, of course), so anyone wanting to experiment can! The formulation includes five total strains, with live A. muciniphila being one of them.

Personally, I would be open to trying Pendulum (and I’ll let you know if I do!), but just keep in mind we do not yet have any data on A. muciniphila supplements in humans with IBD.

There’s also a European company called A-Mansia Biotech that has facilitated much of the recent progress in translational research on Akkermansia muciniphila and has already received $19.8 million in funding. They do not yet have a probiotic on the market, but one of the recent papers associated with the group suggests that given the beneficial effects exerted even when pasteurized, one promising area of research involves investigating which of the bacterial components (particularly Amuc_1100) may be responsible for these benefits, and whether said component could be isolated and developed into a more targeted pharmaceutical. (3)

But if you don’t want to experiment with Pendulum or wait for Amuc_1100 pills, you can still harness the beneficial effects of Akkermansia mucniniphila by doing many of the things you have already been told are good for you. Isn’t it funny how that always seems to be the conclusion we come to?

Some of the things that have been found to increase the abundance of A. muciniphila (but are not necessarily good choices for everyone!) include:

  • dietary polyphenols (59, 60)
  • dietary prebiotics (FODMAPs) (59, 60)
  • supplementation with other probiotics (59)
  • supplementation with prebiotics (fructo-oligosaccharides, inulin) (59, 60)
  • fasting (61, 62) (which makes sense when you consider that with no food coming in, Akkermansia muciniphila is at a distinct advantage being able to survive solely on mucin produced by the host)

It’s also interesting to note that metformin increases A. muciniphila abundance, so that could be a mechanism by which metformin is therapeutic for type II diabetes. (63)

Finally, it’s worth emphasizing that Akkermansia muciniphila is a strict anaerobe, so promoting healthy butyrate production and maintaining an anaerobic colonic environment will help support its growth (and is something you should do anyway for gut health! More on this in my friend Lucy Mailing’s excellent article).

So there you have it! The current status on Akkermansia muciniphila and IBD, as well as I could manage. Any thoughts, comments, experiences – let me know below!

References

  1. Derrien et al. Akkermansia muciniphila gen. nov., sp. nov., a human intestinal mucin-degrading bacterium (2004)
  2. Hojat et al. Global scientific output trend for Akkermansia muciniphila research: a bibliometric and scientometric analysis (2020)
  3. Cani et al. Next-Generation Beneficial Microbes: The Case of Akkermansia muciniphila (2017)
  4. de Vos. Microbe Profile: Akkermansia muciniphila: a conserved intestinal symbiont that acts as the gatekeeper of our mucosa (2017)
  5. Zhang et al. Akkermansia muciniphila is a promising probiotic (2019)
  6. Geerlings et al. Akkermansia muciniphila in the Human Gastrointestinal Tract: When, Where, and How? (2018)
  7. Wang et al. Low relative abundances of the mucolytic bacterium Akkermansia muciniphila and Bifidobacterium spp. in feces of children with autism (2011)
  8. Biagi et al. Through ageing, and beyond: gut microbiota and inflammatory status in seniors and centenarians (2010)
  9. Demirci et al. Reduced Akkermansia muciniphila and Faecalibacterium prausnitzii levels in the gut microbiota of children with allergic asthma (2019)
  10. Swidsinski et al. Acute appendicitis is characterised by local invasion with Fusobacterium nucleatum/necrophorum (2011)
  11. Macchione et al. Akkermansia muciniphila: key player in metabolic and gastrointestinal disorders (2019)
  12. Png et al. Mucolytic Bacteria With Increased Prevalence in IBD Mucosa Augment In Vitro Utilization of Mucin by Other Bacteria (2010)
  13. Earley et al. The abundance of Akkermansia muciniphila and its relationship with sulphated colonic mucins in health and ulcerative colitis (2019)
  14. Vigsnæs et al. Gram-negative bacteria account for main differences between faecal microbiota from patients with ulcerative colitis and healthy controls (2012)
  15. Rajilić-Stojanović, et al. Phylogenetic Analysis of Dysbiosis in Ulcerative Colitis During Remission (2013)
  16. James et al. Abnormal fibre usage in UC in remission (2014)
  17. Magro et al. Remission in Crohn’s disease is accompanied by alterations in the gut microbiota and mucins production (2019)
  18. Lopez-Siles et al. Alterations in the Abundance and Co-occurrence of Akkermansia muciniphila and Faecalibacterium prausnitzii in the Colonic Mucosa of Inflammatory Bowel Disease Subjects (2018)
  19. Zella et al. Distinct Microbiome in Pouchitis Compared to Healthy Pouches in Ulcerative Colitis and Familial Adenomatous Polyposis (2010)
  20. Xu et al. Function of Akkermansia muciniphila in Obesity: Interactions With Lipid Metabolism, Immune Response and Gut Systems (2020)
  21. Zou et al. Engineered Akkermansia muciniphila: A promising agent against diseases (Review) (Dec 2020)
  22. Depommier et al. Supplementation with Akkermansia muciniphila in overweight and obese human volunteers: a proof-of-concept exploratory study (2019)
  23. Perraudeau et al. Improvements to postprandial glucose control in subjects with type 2 diabetes: a multicenter, double blind, randomized placebo-controlled trial of a novel probiotic formulation (2020)
  24. Belzer et al. Microbes inside—from diversity to function: the case of Akkermansia (2012)
  25. King et al. Epithelial-microbial diplomacy: escalating border tensions drive inflammation in inflammatory bowel disease (2019)
  26. Belzer et al. Microbial Metabolic Networks at the Mucus Layer Lead to Diet-Independent Butyrate and Vitamin B 12 Production by Intestinal Symbionts (2017)
  27. van der Lugt et al. Akkermansia muciniphila ameliorates the age-related decline in colonic mucus thickness and attenuates immune activation in accelerated aging Ercc1 -/Δ7 mice (2019)
  28. Ouyang et al. The Bacterium Akkermansia muciniphila: A Sentinel for Gut Permeability and Its Relevance to HIV-Related Inflammation (2020)
  29. Reunanen et al. Akkermansia muciniphila Adheres to Enterocytes and Strengthens the Integrity of the Epithelial Cell Layer (2015)
  30. Li et al. Akkermansia Muciniphila Protects Against Atherosclerosis by Preventing Metabolic Endotoxemia-Induced Inflammation in Apoe-/- Mice (2016)
  31. Everard et al. Cross-talk between Akkermansia muciniphila and intestinal epithelium controls diet-induced obesity (2013)
  32. Plovier et al. A purified membrane protein from Akkermansia muciniphila or the pasteurized bacterium improves metabolism in obese and diabetic mice (2017)
  33. Grander et al. Recovery of ethanol-induced Akkermansia muciniphila depletion ameliorates alcoholic liver disease (2018)
  34. Chelakkot et al. Akkermansia muciniphila-derived extracellular vesicles influence gut permeability through the regulation of tight junctions (2018)
  35. Fujisaka et al. Bofutsushosan improves gut barrier function with a bloom of Akkermansia muciniphila and improves glucose metabolism in mice with diet-induced obesity (2020)
  36. Alam et al. The microenvironment of injured murine gut elicits a local pro-restitutive microbiota (2016)
  37. Alam et al. Role of gut microbiota in intestinal wound healing and barrier function (2018)
  38. Eichele et al. Dextran sodium sulfate colitis murine model: An indispensable tool for advancing our understanding of inflammatory bowel diseases pathogenesis (2017)
  39. Håkansson et al. Immunological alteration and changes of gut microbiota after dextran sulfate sodium (DSS) administration in mice (2014)
  40. Berry et al. Phylotype-level 16S rRNA analysis reveals new bacterial indicators of health state in acute murine colitis (2012)
  41. Liu et al. Akkermansia muciniphila promotes type H vessel formation and bone fracture healing by reducing gut permeability and inflammation (2020)
  42. Derrien et al. Modulation of Mucosal Immune Response, Tolerance, and Proliferation in Mice Colonized by the Mucin-Degrader Akkermansia muciniphila (2011)
  43. Ottman et al. Pili-like proteins of Akkermansia muciniphila modulate host immune responses and gut barrier function (2017)
  44. Ansaldo et al. Akkermansia muciniphila induces intestinal adaptive immune responses during homeostasis (2019)
  45. Kang et al. Extracellular vesicles derived from gut microbiota, especially Akkermansia muciniphila, protect the progression of dextran sulfate sodium-induced colitis (2013)
  46. Ganesh et al. Commensal Akkermansia muciniphila exacerbates gut inflammation in Salmonella Typhimurium-infected gnotobiotic mice (2013)
  47. Bian et al. Administration of Akkermansia muciniphila Ameliorates Dextran Sulfate Sodium-Induced Ulcerative Colitis in Mice (2019)
  48. Zhai et al. Strain-Specific Anti-inflammatory Properties of Two Akkermansia muciniphila Strains on Chronic Colitis in Mice (2019)
  49. Seregin et al. NLRP6 Protects Il10−/− Mice from Colitis by Limiting Colonization of Akkermansia muciniphila (2017)
  50. Ring et al. Akkermansia muciniphila strain ATCC BAA-835 does not promote short-term intestinal inflammation in gnotobiotic interleukin-10-deficient mice (2019)
  51. Desai et al. A Dietary Fiber-Deprived Gut Microbiota Degrades the Colonic Mucus Barrier and Enhances Pathogen Susceptibility (2016)
  52. Khan et al. Dietary simple sugars alter microbial ecology in the gut and promote colitis in mice (2020)
  53. Zhang et al. Chlorogenic Acid Ameliorates Experimental Colitis by Promoting Growth of Akkermansia in Mice (2017)
  54. Zhang et al. Caffeic acid ameliorates colitis in association with increased Akkermansia population in the gut microbiota of mice (2016)
  55. Ma et al. Lactobacillus pentosus Increases the Abundance of Akkermansia and Affects the Serum Metabolome to Alleviate DSS-Induced Colitis in a Murine Model (2020)
  56. Kump et al. The taxonomic composition of the donor intestinal microbiota is a major factor influencing the efficacy of faecal microbiota transplantation in therapy refractory ulcerative colitis (2017)
  57. Earley et al. A Preliminary Study Examining the Binding Capacity of Akkermansia muciniphila and Desulfovibrio spp., to Colonic Mucin in Health and Ulcerative Colitis (2015)
  58. Yaghoubfar et al. Modulation of serotonin signaling/metabolism by Akkermansia muciniphila and its extracellular vesicles through the gut-brain axis in mice (2020)
  59. Zhou. Strategies to promote abundance of Akkermansia muciniphila, an emerging probiotics in the gut, evidence from dietary intervention studies (2017)
  60. Verhoog et al. Dietary Factors and Modulation of Bacteria Strains of Akkermansia muciniphila and Faecalibacterium prausnitzii: A Systematic Review (2019)
  61. Remely et al. Increased gut microbiota diversity and abundance of Faecalibacterium prausnitzii and Akkermansia after fasting: a pilot study (2015)
  62. Özkul et al. Islamic fasting leads to an increased abundance of Akkermansia muciniphila and Bacteroides fragilis group: A preliminary study on intermittent fasting (2019)
  63. Shin et al. An increase in the Akkermansia spp. population induced by metformin treatment improves glucose homeostasis in diet-induced obese mice (2013)

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Hi! I’m Alyssa. This website is where I house all of my musings and investigations and pet research projects – topics ranging from autoimmune disease to nutrition to adult palate expansion to psychology and nervous system therapy. I hope you enjoy this awkwardly cropped poor resolution photo of me playing mini golf. If you want to know more about me, click here!

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Photo dump from the last year. Thanks to everyone Photo dump from the last year. Thanks to everyone who made 28 the best yet - excited for 29🥰

(PS. In case anyone wants to know what it’s like in my head, I was going to write something like “year 28” or “my 28th year” but then I realized that the year between your 28th and 29th birthdays is not your 28th year of life, it’s your 29th year. I am turning 29 because I have been alive for 29 years. So then I had a whole thing about how to word it without being inaccurate and ended up going with what you see above which is vague and weird but the point is it was a good year and I love all the people in my life dearly)
Biology of Belief (2005) was written by Bruce Lipt Biology of Belief (2005) was written by Bruce Lipton, who earned a PhD in developmental biology in 1971 and was an anatomy professor and academic researcher in the 70s and 80s. Despite the book's presentation and Lipton's background, this is not a science book. It is an exposition of an ideology, supported by haphazard and poorly contextualized nuggets of evidence, rhetorical leaps, and a mind-boggling overuse of analogies. 

The book largely failed to deliver on its promised content. What it does is argue for the primacy of the environment over DNA in controlling life; propose that the cell membrane rather than the nucleus is the "brain" of the cell; invoke quantum physics to explain why modern medicine fails; explain that our behavior is largely controlled by our subconscious mind; inform parents that they therefore have a great deal of control over the destiny of their children; and conclude that humans must become nonviolent protectors of the environment and of humanity because Everything Is Connected.

It’s not that these points aren’t relevant to the topic at hand - they are. But they were not connected in a coherent way that would explain how “belief” actually works (like…biologically), and the treatment of scientific concepts throughout was careless, or perhaps disingenuous.

I think he's correct about many things, some of them being common knowledge. For instance, the "new" science of epigenetics is now old news, as is the critical role of parenting and early environment in shaping a child’s future. But however important these and attendant concepts may be, the book did not do a good job explaining, supporting, or connecting them. 

As far as practical guidance, he refers the reader to a list of resources on his website, which is fine, but I expected some scientific insight into how/why those modalities work. None was given. 

On the plus side, the book was quite thought-provoking, and I came away with loads of references and topics to follow up on. My favorite line? "There cannot be exceptions to a theory; exceptions simply mean that a theory is not fully correct."
Friedrich Nietzsche, The Gay Science (section 382) Friedrich Nietzsche, The Gay Science (section 382), as quoted in the introduction to Thus Spoke Zarathustra because I like the translation better.
This paper totally changed the way I think about e This paper totally changed the way I think about early nervous system development and the relationship between physiology and sociality. 

The authors propose that newborn babies are not inherently social, and have just one goal in life: physiological homeostasis. I.e. staying alive. This means nutrients, warmth, and regulation of breath and heart rate, i.e. autonomic arousal (it’s well-accepted that newborns sync their breathing and heart rate with caregivers through skin to skin contact). 

All these things are traditionally provided by a loving caregiver. So what the baby experiences during the first weeks of life, over and over, is a shift from physiological perturbation to homeostasis (a highly rewarding event inherently) REPEATEDLY PAIRED with things like the sound of a caregiver’s voice and seeing their face. Thus, over time, the face/voice stimuli become rewarding as well. 

The authors argue that THIS is the beginning of humans’ wiring for sociality, and may explain why loving social interactions can have such a profound regulating effect on physiology throughout life: because the brain was trained for it at an early age. 

This framework holds all kinds of fascinating implications for what happens if that initial “training” isn’t so ideal. What if the return to nutritional homeostasis via feeding is paired with negative expressions and vocalizations rather than loving ones, perhaps as could occur with PPD? What happens if the caregiver has poor autonomic regulation, such that social stimuli become paired with cardiorespiratory overexcitement in the baby? Could that have potential for influencing later introversion vs extroversion? (Because if social interaction is paired with autonomic overexcitement, that could lead to social interaction literally being more energetically draining, which is what introverts experience. Thoughts?)

For my energy metabolism enthusiasts: Table 1 in the paper draws a link between metabolic rate and sociality across species. Swipe for a screenshot. 

Anyway, check out the paper! It’s free, just google “growing a social brain pdf.”
I’ll be under general anesthesia in a couple day I’ll be under general anesthesia in a couple days to have two tooth implants placed, and I think I’ll take the opportunity to have a little heart-to-heart with my subconscious mind. A bit of medically-assisted self-hypnosis, if you will. 

I randomly stumbled upon these papers a couple months ago - an RCT showing reduced post-op pain in patients who listened to recorded positive messages while under general anesthesia, plus a post-hoc analysis of the same data that found reduced post-op nausea and vomiting in a subset of high-risk patients. 

The full review paper from the first slide is unfortunately in German, but it has long been recognized that even when unconscious, the patient is listening (for better or for worse). 

It boggles my mind that it isn’t standard of care to have patients listen to recordings like this while under sedation, considering that almost nothing could be easier, safer, or cheaper, and we have at least some evidence of significant efficacy. I mean c’mon, what more could you want from an intervention? 

(Yeah, I know. Profit. If anyone still thinks that our medical system operates with patient well-being as the foremost goal, you’re deluding yourself.)

“There should be a fundamental change in the way patients are treated in the operating room and intensive care unit, and background noise and careless conversations should be eliminated.”

“Perhaps it is now time to finally heed this call and to use communication with unconscious patients that goes beyond the most necessary announcement of interventions and is therapeutically effective through positive suggestions. When in doubt, assume that the patient is listening.”
If you've seen "vagus nerve exercises" that have y If you've seen "vagus nerve exercises" that have you moving your eyes or tilting your head, you've probably encountered the work of Stanley Rosenberg. The exercises he created and introduced in his 2017 book now appear in instructional videos all over the internet. 
 
The book itself has much to recommend it: it's accessible, it's practical, it's inspiring. But it has one major flaw: the solid practical and informational content regarding the cranial nerves is framed in terms of the scientifically dubious polyvagal theory. 
 
I particularly enjoyed the book as an introduction to the therapeutic arena of bodywork, of which Rosenberg is a skilled practitioner. His book is full of case reports that demonstrate how immensely powerful extremely subtle movements and physical manipulations can be. These do need to be kept in perspective: it's a small sample size of the most remarkable cases, and the results were achieved within the supportive clinical environment of a skilled practitioner. You can tell from his descriptions how refined his technique is. But nevertheless, it was a paradigm-shifting read for me, and the exercises give you something concrete to play around with. 
 
The book also brought the cranial nerves and the concept of “social engagement” to the fore as arbiters of health. Rosenberg has a solid background in cranial nerve anatomy and shares many interesting tidbits and considerations that you don’t typically hear; for instance, the potential impact of dental and orthodontic work on cranial nerve function.
 
So, is it worth reading? If any of the above piques your interest, go for it! Just read my post on polyvagal theory first – you can use the book to practice separating the wheat (solid informational content) from the chaff (pseudoscientific framing). If nothing else, the book is a nice reminder that genuine healers who get lasting results for their patients do exist.

But if you just want to try the exercises, you can easily find them all on YouTube. 

“You learn techniques to understand principles. When you understand the principles, you will create your own techniques.” -Stanley Rosenberg
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